All the Side effects of dupilumab explained

Dupilumab is a biologic drug used to treat moderate to severe eczema. It is also used to treat long-term rhinosinusitis with nasal polyps and moderate to severe eosinophilic asthma.

1. Joint pain

Some people may experience joint pain while receiving Dupilumab. But, a study said that people who took Dupilumab for rhinosinusitis with nasal polyps only had this side effect and it was not very common.

What to do if you have joint pain while receiving dupilumab?

  • Applying hot or cold packs.
  • Try swimming, it can help with joint pains and does not strain the body.

If you have really bad joint pain, then it is best to consult a doctor and get the treatment required.

2. Eye-related side effects

Mild eye-related side effects that can occur when receiving dupilumab are:

  • conjunctivitis 
  • blepharitis
  • dry eyes or itchy eyes

Serious eye-related issues like keratitis can also occur. If left untreated, it can damage your eyesight or cause problems, such as corneal ulcers. Some symptoms of eye-related side effects include red eyes, eye itchiness, eye discharge, crusty or swollen eyelids, eye dryness, eye pain, and changes in vision.

If you do experience these side effects and if they become serious, do consult a doctor immediately.

3. It may cause eosinophilic conditions

Dupilumab may sometimes increase the number of eosinophils (white blood cells) in your blood. An increase in eosinophils can cause inflammatory conditions (like pneumonia and vasculitis). Some symptoms of eosinophils are skin rash, worsening shortness of breath, chest pain, fever, tingling, prickling, or numbness in the arms or legs. This side effect is very rare.

4. Injection site reactions

This is the most common side effect that people get when receiving dupilumab. Some symptoms of injection site reactions are redness, pain, bruising, swelling, and itching. To avoid injection site reactions, inject into different areas each time you give yourself a dose of Dupilumab (make a note of the day and the area where you injected it as a reminder). These are called rotating injection sites.

Also, make sure to not inject into the areas where the skin is tender, bruised, damaged, or scarred.

5. Allergic reactions

Allergic reactions are also very common when receiving dupilumab. Some symptoms are skin rash, itchiness, flushing, swelling under your skin (eyelids, lips, hands, or feet), and swelling of your mouth, tongue, or throat, which can make it harder to breathe and eat.