Dupilumab for Allergic Bronchopulmonary Aspergillosis 

ABPA is treated with a combination of oral corticosteroids and anti-fungal medications. Inhaled corticosteroids are not effective in treating ABPA and treatments with oral corticosteroids are needed for months. The second type of treatment used is an anti-fungal medication, like itraconazole and voriconazole. These medicines help kill Aspergillus (a fungus) so that it no longer colonizes the airway. Usually, one of these drugs is given for at least 3 to 6 months. However, even this treatment does not cure you of ABPA and can have side effects.

There are some studies showing that dupilumab can be used in the treatment of ABPA, but it has not been approved by any regulatory authority. It is currently in clinical development by Regeneron (a leading biotechnology company that made dupilumab) where dupilumab is able to treat type 2 inflammatory diseases and ABPA is one of them.