Dupilumab for eosinophilic esophagitis

Eosinophilic esophagitis is a chronic inflammatory disorder ( in which eosinophils, a type of white blood cell) are found in the tissue of the esophagus. Common symptoms of eosinophilic esophagitis include difficulty swallowing, difficulty eating, and food getting stuck in the esophagus.

The FDA has approved the use of dupilumab for eosinophilic esophagitis in adults and pediatric patients (12 years and older weighing at least 40 kilograms).

The efficacy and safety of Dupilumab in eosinophilic esophagitis were studied in a randomized, placebo-controlled trial, that included two 24-week treatment periods (Part A and Part B) that were conducted independently in separate groups of patients. In Part A and Part B, patients received either a placebo or 300 milligrams of Dupixent every week. The two primary measurements of efficacy were patients who achieved a certain level of reduced eosinophils in the esophagus at week 24, and the change in the patient-reported Dysphagia Symptom Questionnaire (DSQ The DSQ is a questionnaire designed to measure difficulty swallowing associated with EoE) score from baseline to week 24.

In Part A of the trial, 60% of the 42 patients who received Dupixent achieved the level of reduced eosinophils in the esophagus compared to 5% of the 39 patients who received a placebo. In Part A patients who received Dupixent experienced an average improvement of 22 points in their DSQ score compared to 10 points in patients who received placebo. In Part B, 59% of the 80 patients who received Dupixent achieved the level of reduced eosinophils in the esophagus compared to 6% of the 79 patients who received a placebo. In Part B patients who received Dupixent experienced an average improvement of 24 points in their DSQ score compared to 14 points in patients who received placebo. dupilumab was able to improve dysphagia.

You can have some side effects while receiving dupilumab, but it is safe to use in the treatment of eosinophilic esophagitis.

For more information, you can consult your doctor and get the treatment required.