Epsolay (benzoyl peroxide) Cream 5% for Rosacea

Epsolay is a topical cream containing benzoyl peroxide (5%) used for the treatment of inflammatory lesions (bumps, skin marks, pustules, and papules) of rosacea in adults.

Epsolay works by using microencapsulation technology. So, basically, the Epsolay cream is designed with microcapsules that control the release of benzoyl peroxide on your skin.

These microcapsules gradually (slowly) release benzoyl peroxide on your skin to relieve rosacea. This makes our skin tolerable to it and we can use the cream daily or as prescribed.

What should I tell my doctor before using Epsolay cream?

Before using Epsolay Cream, tell your doctor about all of your medical conditions, including if you:

  • have any other skin problems, including cuts, eczema, or sunburn.
  • are pregnant or planning to become pregnant. It is not known if Epsolay cream can harm your unborn baby.
  • are breastfeeding or planning to breastfeed. It is not known if Epsolay cream can pass into your breast milk.
  • Tell your doctor about all the medicines you take, including over-the-counter medicines, prescriptions, vitamins, and herbal supplements.

How to use Epsolay cream?

  • Use a mild cleanser to rinse your face, and pat dry with a soft towel.
  • Apply a pea-sized amount of Epsolay cream once daily (morning or night) onto each area of your face (forehead, chin, nose, and cheeks). Avoid your lips, eyes, and mouth.
  • Wash your hands, as the cream may bleach or stain fabric.
  • Use a moisturizer and sunscreen.

Note: Do not use Epsolay cream in your eyes, mouth, or vagina.

How long will it take to see results?

You can see results in 2 weeks but for some people, it might take more time to see results.


Patients who have a history of serious hypersensitivity reactions to benzoyl peroxide or any component of the formulation in EPSOLAY.

What are the possible side effects of Epsolay?

Common side effects include:

  • pain
  • swelling
  • itching
  • skin irritation, and
  • redness of skin

Serious side effects include:

Allergic reactions:

  • hives, rash, or severe itching
  • swelling of your eyes, lips, face, tongue, or throat
  • trouble breathing or throat tightness
  • dizziness

Warnings and Precautions


You may experience hypersensitivity reactions, including acute allergic reactions, rapid swelling, and hives. If a serious hypersensitivity reaction occurs, you will have to discontinue the use of Epsolay Cream immediately and seek medical attention.

Skin Irritation/Contact Dermatitis

You may also experience skin irritation or contact dermatitis, including redness, scaling, dryness, and stinging/burning. You can use a moisturizer to help with the side effects but discontinue the product if your symptoms do not improve.

Avoid application to abrasions, cuts, eczematous, or sunburned skin.


Epsolay Cream may increase photosensitivity or sensitivity to ultraviolet light. Try to avoid exposure to artificial sunlight like tanning beds or UVA/B treatment. Use sunscreen and protective clothing when sun exposure cannot be avoided. If you get a sunburn, discontinue the use of Epsolay Cream.

What are the ingredients in EPSOLAY Cream?

Active ingredient: benzoyl peroxide
Inactive ingredients: anhydrous citric acid, lactic acid, macrogol stearate Type I, mono and di-glycerides,
phenoxyethanol, polyquaternium-7, cetrimonium chloride, cetyl alcohol, Cyclomethicone, edetate
disodium, glycerin, hydrochloric acid, purified water, silicon dioxide, and sodium hydroxide.

How should I store EPSOLAY Cream?

  • Store Epsolay cream at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep Epsolay cream away from heat.
  • keep Epsolay cream out of the reach of children.
  • Do not freeze Epsolay cream.
  • Throw away the unused Epsolay cream 30 days after first use.