Ailanthus altissima was used in traditional medicine for the treatment of dysentery, gonorrhea, and hemorrhoids, and as a remedy for cough, gastric and intestinal upsets. The bark is prescribed to treat diarrhea, anemia, hemorrhage, and spermatorrhea. It is also used as an antispasmodic, antiasthmatic, cardiac depressant, astringent, and for the treatment of epilepsy.
What are the benefits of Ailanthus altissima bark extract?
- Antimicrobial effects: The antibacterial effects of Ailanthus altissima bark extract were evaluated by the agar disk diffusion method against 11 foodborne bacteria. It inhibited significantly the growth of all six gram-positive bacteria and two gram-negative bacteria.
- Anti-viral effects: The methanolic stem bark extract of Ailanthus altissima showed potent anti-HIV activity meaning that it could help in the treatment of HIV.
- Antidiarrhoeal effects: the methanolic extract of root bark of Ailanthus altissima was investigated for anti-diarrhoeal activity in castor oil induced-diarrhea and small intestine transit method on mice. The bark extract of Ailanthus altissima 200 mg/kg reduced the total weight of the feces.
- Antioxidant effect: the bark extract of Ailanthus altissima also shows excellent scavenging of free radicals and its ability to reduce oxidative stress and aging.
- Effect on age-related disorders: there are studies showing that four terpenylated coumarins from Ailanthus altissima have a direct stimulatory effect on SIRT1 deacetylation activity and can serve as lead molecules for the treatment of some age-related disorders.
- Other pharmacological properties: anti-inflammatory, analgesic, antipyretic, and antihistaminic effects.
- Anti-progestogenic effects: Ailanthus altissima was evaluated for progestogenic and anti-progestogenic properties and was recognized to have antiprogestogenic-like activities.
What are the side effects of Ailanthus altissima bark extract?
There are reports of contact dermatitis and allergic reactions to the extract. However, large doses of the drug are said to lead to queasiness, dizziness, headache, tingling in the limbs, and diarrhea. Fatal poisonings have been observed in animal experiments. Treatment of poisonings should be conducted symptomatically, following stomach and intestinal emptying.
What is the recommended dosage?
Ailanthus altissima is still being researched as a drug, the prescribed daily dose: is 6 to 9 gm of the drug.