Dupilumab for Chronic Rhinosinusitis with Nasal Polyps
Dupilumab is a biologic drug that inhibits IL-4 and IL-13 (receptors), which are the major factors of type 2 inflammatory diseases like asthma, eczema, and chronic rhinosinusitis with nasal polyps. It is the first biological therapy to be approved for the treatment of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the EU and the USA. A case study showed that the addition of dupilumab (300 mg every 2 weeks) to the corticosteroid treatment of adults with severe, inadequately controlled CRSwNP improved: Nasal polyp size Sinus opacification and health-related quality of life It relieved nasal congestion or obstruction, nasal discharge, and loss of smell which are the major symptoms of CRSwNP.…
Dupilumab for eczema – Is it really the cure for inflammatory diseases?
What is Dupilumab? Dupilumab (also known as Dupixent) is used to treat severe atopic eczema. It is a biologic drug and works in a way that is different from the other drugs used for treating eczema. They are taken in different ways like – injection (just below the skin, in the vein) and also orally. Dupilumab is the first biologic drug used to treat eczema and it comes as a ready-to-use syringe with a needle or it will be a pre-filled injector pen. There are other biologic treatments currently being developed to treat atopic eczema. How does Dupilumab work? Our body uses chemical messengers called interleukins (ILs) and it allows…
Dupilumab for Bullous Pemphigoid
Dupilumab is a biologic drug that can treat moderate to severe eczema, asthma, and chronic rhinosinusitis with nasal polyposis. It is also used to treat a skin disease called Bullous pemphigoid (BP). BP is an autoimmune skin disease that results in the formation of pruritic blisters and it mainly affects older people. Let’s look at some case studies on how dupilumab can be an effective treatment for bullous pemphigoid: 1. A case study consisted of 13 patients (average age of 76.8 years) and the average duration of BP before dupilumab initiation was 28.8 months. After the initiation of dupilumab, a satisfactory response was achieved in 92.3% (12 of 13) of the patients.…
All the Side effects of dupilumab explained
Dupilumab is a biologic drug used to treat moderate to severe eczema. It is also used to treat long-term rhinosinusitis with nasal polyps and moderate to severe eosinophilic asthma. Side effects explained: 1. Joint pain Some people may experience joint pain while receiving Dupilumab. But, a study said that people who took Dupilumab for rhinosinusitis with nasal polyps only had this side effect and it was not very common. What to do if you have joint pain while receiving dupilumab? Applying hot or cold packs. Try swimming, it can help with joint pains and does not strain the body. If you have really bad joint pain, then it is best to consult…
Topical calcineurin inhibitors for eczema
What are topical calcineurin inhibitors? Topical calcineurin inhibitors work by altering the immune system and it helps to treat atopic eczema. There are two types of topical calcineurin inhibitors (TCIs): Tacrolimus ointment (Protopic) used for treating moderate to severe eczema. Pimecrolimus cream (Elidel) used for treating mild to moderate eczema. Topical calcineurin inhibitors are used to treat atopic eczema in adults and children over 2 who don’t respond or who cannot tolerate conventional therapies such as topical steroids. They are used to treat and prevent flares. When can topical calcineurin inhibitors be used? TCIs are suitable for delicate areas of the skin, such as the face, eyelids, neck, skin folds,…
Pompholyx eczema – The complete guide
Pompholyx eczema is also known as dyshidrotic eczema. It is a type of eczema that affects the hands and feet. In most cases, it can develop into itchy, watery blisters, mostly affecting the sides of the fingers, palms of the hands, and the soles of the feet. Some people also have a combination of pompholyx eczema and other types of eczema on their hands and feet. It is more common in women. What causes pompholyx eczema? The exact causes of pompholyx eczema are not known, but it is thought that factors such as sensitivity to metal (compounds such as nickel, cobalt, or chromate), stress, heating, and sweating can aggravate this…
Discoid eczema – The complete guide
Discoid eczema is a common type of eczema. It looks like an oval or round lesion and it can be very itchy. Who all can get discoid eczema? Discoid eczema is also known as nummular eczema or dermatitis. It can occur at any age including, childhood, but it is more common in adult males. Anyone can get discoid eczema, but people with atopic eczema, infected eczema, or allergic contact dermatitis are more likely to develop it. It can also develop in those who had eczema as a child. It also has an association with chronic alcoholism. What causes discoid eczema? There are many causes of discoid eczema. they are as…
Asteatotic eczema – Complete guide
Asteatotic eczema is also known as eczema craquelé. It is another form of eczema that is more common in older people. It usually affects the shins, but can also affect other areas such as the thighs, tummy, arms, and back. If your home is warm and dry during the winter, you will be prone to develop this type of eczema. In asteatotic eczema, the skin becomes very dry, scaly, and rough. What causes asteatotic eczema? Drying of the skin (more common during the winter season) can cause epidermal water loss and this will lead to asteatotic eczema. Medications such as diuretics can increase the drying effect. Other factors include decreased…
Chaenomeles sinensis fruit extract for skin
Chaenomeles sinensis fruit extract is an extract that is used in traditional Chinese medicine. Benefits of using Chaenomeles sinensis fruit extract: Who all can use Chaenomeles sinensis fruit extract? Chaenomeles sinensis fruit extract should be suitable to use for all skin types including sensitive skin and skin of colour, but make sure that you’re not allergic to this extract.
Lindera Strychnifolia root extract for Skin and Hair
Lindera strychnifolia or Uyaku is a root extract used in traditional Asian medicine to treat stomach and renal diseases, neuralgia, rheumatism, and aging. What are the benefits of lindera strychnifolia root extract? Antioxidant: it can help to scavenge free radicals, reduce oxidative stress and protect the skin. Anti-Allergic and anti-Inflammatory activities: there are studies showing that eight phenolic glycoside compounds isolated from lindera strychnifolia root extract show strong anti-allergic and anti-inflammatory activity and can, therefore, be further developed into effective therapeutic agents with modification. Anti-tyrosinase: it also displays anti-tyrosinase activity meaning that it can be used in skin whitening cosmetics. Helps with hair loss: A study showed that Lindera strychnifolia root extract…